questionshow to lock or hide entire hard drive?

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I don't know of any way to make it so the drive is not seen by anyone if it's an internal drive but TrueCrypt has a feature that allows you to encrypt an entire partition with "plausible deniability". This makes it so it's not possible to tell if there's an encrypted volume stored on the drive. The drive is still visible but you will not see any files on it. Someone could re-partition the drive and wipe out your data because they don't know something important is there.

If you want people to avoid the drive completely, use an external USB drive and take it with you when you leave.

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Windows as a "file access" feature that's related to the user login account. If someone other than you logs in to the machine, the drive will still be visible, but if someone tries to view the contents, they'll get an "access denied" message and will not be able to go any farther.

The specific way of doing this may be slightly different for different versions of Windows and I have no idea what to do with a Mac('n'Cheese) computer. I suggest you Google something like "access denied" and "file permissions" and your OS, and you should be able to find the answer.

Of course a USB drive is also a good idea, depending on the amount of data. I use a Maxell 16GB USB stick that also has built-in password access. I carry it with me when I'm not at the computer. Even if someone were to get hold of it, without my password they couldn't access the files. (A duplicate copy lives in my safe deposit box, as well.)

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If you are using Win 7, Win 8, or Enterprise, Ultimate version of Vista, you can find Bitlocker feature in control panel, this is a free protection function for hard drive. But if you are running other operating systems, you'd better use third party software such as Advanced Folder Encryption software(http://www.kakasoft.com/folder-encryption) or TrueCrypt(http://www.truecrypt.org). The former one can only lock and hide the hard drive but not encrypt it. The latter one can encrypt the entire hard drive, but its encrypting process is a little complicated.

Hope my answer can help you.