questionsanybody know the difference between the fujitsu…

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I recently looked into that portable scanner and went with this one instead since it supports TWAIN http://www.amazon.com/Canon-imageFORMULA-Scan-tini-Personal-Document/dp/B003HJ114A/ref=pd_sim_e_30

But, to answer your question, the portable model will hold fewer sheets in the feeder, probably not feed quite as well (more jams, grabbing two pages at once, etc) and will likely run pages through slower. I assume there are other differences too but those are the main things I have noticed when comparing the portable Canon to the desktop scanner we have.