Based on the novel by Hubert Selby Jr., this gritty drama concerns four people trapped by their addictions. Harry (Jared Leto), and his best friend Tyrone (Marlon Wayans) are impoverished heroin addicts living in Coney Island, NY, while Harry's girlfriend Marion (Jennifer Connelly) is a fellow addict trying to distance herself from her wealthy father. Harry dreams of scoring a pound of smack, from which he could make enough money to open a clothing boutique with Marion, but so far he and his friends can barely scrape by supporting their own habits. Meanwhile, Harry's mother Sara (Ellen Burstyn), who spends her days watching television, is told she has the opportunity to appear on her favorite game show; wanting to lose enough weight to fit into her favorite red dress, she visits a sleazy doctor who gives her a prescription for amphetamines. Soon Sara has a drug habit of her own that is spiraling out of control.